Topics covered in the questionnaire are: household members and their characteristics, household income, availability of services, demographic information, medical history, health risk behaviours, symptom history, access to COVID-19 prevention measures, self-perceived risk, and travel habits or physical distancing. A total of 10 109 VPs were approached to participate in the survey, of the 10 109 VPs approached, 5 580 agreed to participate, giving a household response rate of 55%. Of all the VPs approached, 43.1% refused to take part in the survey, and 1.6% of the valid VPs were unoccupied or empty. A total of 16 646 individuals were eligible to participate in the study, of whom 90.87% agreed to be interviewed. Of those who were eligible, 81.9% completed the interview and provided blood specimens. The data set available for dissemination contains 15 127 cases and 156 variables.